Multi-point selection tool

To verify the success of the different deposition steps, in combination with the Split Pool methodology X-ray fluorescence was chosen as an analysis tool. Elemental analysis was performed by X-ray fluorescence analysis on an Eagle II pProbe (Roentgenanalytik) with Rh-Ka radiation. An essential feature is the small diameter of the measurement spot The X-ray beam is focused by a multi-capillary system to a 50 pm spot on the sample surface. XRF analysis of the 8x12 catalyst library selection (Fig. 2.20) was routinely accomplished automatically by an elemental mapping at a pattern of 512x400 points, equally distributed over the rectangular library field, each point (50 pm diameter) was measured for 300 ms. 

The ideal detector is universal yet selective, sensitive and structurally informative. Mass spectrometry (MS) currently provides the closest approach to this ideal. The combination of multi-dimensional gas chromatography with high resolution MS or mass-selective detectors in the single ion monitoring (SIM)-mode is currently the most potent analytical tool in enantioselective analysis of chiral compounds in complex mixtures [29]. Nevertheless, it must be pointed out that the application of structure specific detection systems like MS [51] or Fourier transform infrared (FT-IR) [52] cannot save the fundamental challenges to optimum (chiral) resolutions and effective sample clean-up [53]. 

The last chapter provides a look at selected applications of multi-way analysis that have appeared in the chemometrics literature. This section of the book is not meant to be a complete literature review of the subject. Rather, applications were selected to aid the reader in understanding what the tools can do and hopefully point the way for the reader to discover new applications in his/her own field of investigation. 

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