Mucociliary system

B. Petruson, H. A. Hansson, and G. Karlsson. Structural and functional aspects of cells in the nasal mucociliary system. Arch Otolaryngol 110 576-581 (1984). 

D. F. Proctor. The mucociliary system. In D. F. Proctor and I. Andersen (eds.), The Nose Upper Airway Physiology and the Atmospheric Environment, Elsevier Biomedical Press, Amsterdam, 1982, pp. 245-305. 

Ohashi, Y, Nakai. Y, Koshimo, H., Esaki, Y, Ikeoka, H., Horiguchi, S.. Teramoto, K. Nakaseko. H. (1988) Toxicity of isopropyl alcohol exposure on the nasal mucociliary system in the guinea pig. Environ. Res., 46, 25-38... 

The nasal application of drugs is an area of growing interest (21) and a number of publications has shown that simple molecules as well as more complex species (eg calcitonin, insulin etc) can be well absorbed by this route, either directly or in the presence of so-called absorption enhancers. One problem with such materials could be too rapid clearance of the delivery system from the nasal cavity through the efficient action of the mucociliary system. For this reason Ilium has considered the use of microsphere systems. 

The defense system of the airways includes both the innate, nonadaptive defense at the level of the mucociliary system and the adaptive immune response. Special attention will be given to the innate defense system as an important first-line defense against inhaled microorganisms. 

Wang J, Bu G. Influence of the nasal mucociliary system on intranasal drug administration. Chin Med J (Engl). 2000 113(7) 647-9. 

Deitmer T. Physiology and pathology of the mucociliary system. In lYaltz CR, ed. Advances in Oto-Rhino-Laryngology. Basel Karger, 1989 1-136. 

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