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Mucoadhesives ocular

Das, S.K., et al. 1995. Evaluation of poly(isobutylcyanoacrylate) nanoparticles for mucoadhesive ocular drug delivery. I. Effect of formulation variables on physicochemical characteristics of nanoparticles. Pharm Res 12 534. [Pg.520]

Poly(acrylic acid) (PAA) (Figure 16.5) is an anionic mucoadhesive polymer produced by the radical polymerization of acrylic add. PAA and its derivatives—weakly crosslinked PAAs, also known as Carbomers or Carbopol—are widely used in ophthalmic formulation, such as the ones used for the management of the dry eye condition. Generally, PAA and its derivatives are used in the preparation of mucoadhesive ocular drug delivery formulations [25], either in the form of viscous gels [26], nanoparticles... [Pg.447]

NM Davies, SJ Farr, J Hadgraft, IW Kellaway. (1991). Evaluation of mucoadhesive polymers in ocular drug delivery. I. Viscous solutions. Pharm Res 8 1039-1043. [Pg.376]

MF Saettone, D Monti, MT Torracca, P Chetoni. (1994). Mucoadhesive ophthalmic vesicles Evaluation of polymeric low-viscosity formulations. J Ocular Pharmacol 10 83-92. [Pg.376]

CM Lehr, YH Lee, VHL Lee. (1994). Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit. Invest Ophthalmol Vis Sci 35 2809-2814. [Pg.390]

The following types of mucoadhesive preparations have been evaluated for ocular drug delivery hydrogels, viscous liquids, solids (inserts), and particulate formulations [57]. Hui and Robinson [58] introduced hydrogels consisting of cross-linked polyacrylic acid for ocular delivery of progesterone in rabbits. These preparations increased progesterone concentrations in the aqueous humor four times over aqueous suspensions. [Pg.181]

Using a new approach that involves the utilization of the mucoadhesive property of polymers to improve the ocular absorption of poorly absorbed drugs. [Pg.532]

Given the considerable challenge of ocular drug delivery, i.e. short contact time and low drug bioavailability, mucoadhesives are attractive excipients in ophthalmic drug formulations. The presence of mucin in the eye allows bioadhesive polymers to thicken the tear film in the front of eye. [Pg.309]

Ludwig, A. (2005),The use of mucoadhesive polymers in ocular drug delivery, Adv. Drug Deliv. Rev., 57,1595-1639... [Pg.1363]

Davies, N.M. Farr, S.J. Hadgraft, J. Kellaway, I.W. Evaluation of mucoadhesive polymers in ocular drug dehvery. J. Viscous Solutions. Pharm. Res. 1991, 8, 1039-1043. [Pg.1181]

Shen, J., Wang, Y, Ping, Q., Xiao, Y, and X. Huang. Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. J Control Release, 137 (2009) 217-223. [Pg.489]

Mucoadhesive Polymers as the Penetration Enhancers in Ocular Drag Delivery... 1212... [Pg.1168]


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