Mu opioid receptor agonists

Glaum SR, Miller RJ, Hammond DL (1994) Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. 

Choi Y, Chuang LF, Lam KM, Kung HF, Wang JM, Osburn BI, Chuang RY (1999) Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor agonists. In Vivo 13 389-396... 

Mucha RF, Herz A Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology 86 274-280, 1995... 

Szeto, H. (Cornell Research Foundation) Mu-opioid receptor agonist peptide, W00205748 (2002). 

Glatzer NR, Smith BN (2005) Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1. J Neurophysiol 93 2530-40 Glaum SR, Miller RJ, Hammond DL (1994) Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. J Neurosci 14 4965-71... 

Osborne, P. B., Chieng, B., and Christie, M. J. (2000). Morphine-6/3-glucronide has a higher efficacy than morphine as mu-opioid receptor agonist in the rat locus coeruleus. By. J. Pharmacol. 131, 1422-1428. 

The clinical evaluation of benzhydrylpiperazines is underway at Ardent Pharmaceuticals, with an injectable mixed delta/mu opioid receptor agonist in trials for the treatment of severe pain. With the development of delta receptor selective opioid agonists with optimized pharmacokinetic properties, other benzhydrylpiperazines (or related agents) are expected to undergo clinical evaluation for the treatment of a variety of indications. Synthetic routes are available to construct these compounds on a reasonable scale and to allow the further development of manufacturing processes. 

Wagner EJ, Zhang W, LaGrang A, Ronnekleiv O, Kelly M (1997) Tolerance to mu-opioid receptor agonists but not cross-tolerance to y-aminobutyric acid B receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. J Pharmacol Exp Ther 250 1057-1064. 

Hornfeldt CS, Smullin DH, Schamber CD, Sun X, Larson AA (1992) Antinociceptive effects of intrathecal taurine and calcium in the mouse. Life Sd 50 1925-1934 Horvath G (2000) Endomorphin-1 and endomorphin-2. Pharmacology of the selective endogenous mu-opioid receptor agonists. Pharmacol Ther 88 437-463 Horvath G, Agil A, Joo G, Dobos 1, Benedek G, Baeyens JM (2003) Evaluation of endomorphin-1 on the activity of Na, K -ATPase using in vitro and in vivo studies. Eur J Pharmacol 458 291-297... 

Bradley CM, Nicholson AN. Effects of a mu-opioid receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man. Br J Chn Pharmacol 1986 22(5) 507-12. 

Choudry NB, Gray SJ, Posner J, Fuller RW (1991) The effect of 443C81, a mu opioid receptor agonist, on the response to inhaled capsaicin in healthy volunteers. Br J Clin Pharmacol 32 ... 

Wagner KJ, Valet M, Kochs EF, Kriner M, Tolle TR, Sprenger T. The mu-opioid receptor agonist remifentanil induces acute dysphoria irrespective of its analgesic properties. J Psychopharmacol 2010 24(3) 355-61. 

Sufentanil is a potent mu opioid receptor agonist. Like other opioids, its major and minor sites of action are... 

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