MR domain

The system of Equations 5.228 and 5.229 was solved numerically using Maple software. Figure 5.36a shows the shape of normalized methanol concentration and membrane potential . Equation 5.219 prescribes rapid decrease of Cmi from unity to zero at X = 5 cm (Figure 5.36a). As can be seen, this decrease induces the drop of membrane potential by 450 mV (from —0.25 V in the MR-domain down to —0.7 V in the MD-domain, Figure 5.36a). 

Perret D, Shields M, Saxon A, Kehry MR A mouse Fey Fee protein that inhibits mast cells through activation of FcyRIIB, SH2 domain-containing inositol SS phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases. J Allergy Chn Immunol 2008 121 441-447. 

Annexin V-functionalized crosslinked iron oxide (CLIO) was designed as a contrast agent for MRI, which was additionally labeled with Cy5.5 to allow colocalization with optical imaging techniques [98]. Alternatively, conjugation of multiple Gd-DTPA molecules or SPIO particles to the C2 domain of synaptotagmin I was shown to allow the detection of apoptotic cells in vitro [99]. Zhao et al. [100] were the first to apply a C2 domain-functionalized SPIO and showed very promising results for future in vivo applications of MR contrast agents for the detection of apoptotic sites. 

Soluble forms of guanylyl cyclase are activated by nitric oxide. These enzymes are homologous to the catalytic domains of the membrane-bound forms of GC. They are considered heterodimers because they appear to exist, under physiological conditions, as complexes of a and P subunits, each with Mr of 70-80 kDa. Both types of soluble GC contain three primary domains an amino-terminus heme domain responsible for binding nitric oxide (NO), a dimerization domain and a carboxy terminus catalytic domain. The aP heterodimer is required for enzyme activity [35]. This can be seen as similar to the situation for AC, which contains two catalytic entities within a single polypeptide chain (Fig. 21-5). 

Figure 10.11 Comparison of the structures of MR, MLE and enolase showing the two homologous domains that illustrate divergent evolution. (From Gerlt et al., 2005. Copyright 2005, with permission from Elsevier.)...

Cahn, R.W. (1987) Antiphase domains, disordered films and the ductility of ordered alloys based on Ni3AT. In High-Temperature Ordered Intermetallic Alloys II, eds. Stoloff, N.S., Koch, C.C., Liu, C.T. and Izumi, O. (MRS, Pittsburgh), Vol. 81, p. 27. 

The Ca2+ pump of the sarcoplasmic reticulum, which comprises 80% of the protein in that membrane, consists of a single polypeptide (Mr -100,000) that spans the membrane ten times and has three cytoplasmic domains formed by loops that connect the transmembrane helices (Fig. 11-38). The two Ca2+-binding sites are located near the middle of the membrane bi-... 

The structures of most larger proteins (Mr > 20 000, or sequences of greater than —200 residues) appear to be composed of independently folded globular units called domains. The definition of a domain is not rigorous. The residues within a domain are seen to interact more with one another than they do with residues in different domains. 

G proteins have a common core structure, the G domain of Mr about 21 000, that is virtually superimposable in all crystal structures so far solved.66-74... 

---