MPA methylprednisolone acetate

Abbreviations-. MPA, methylprednisolone acetate HCA, hydrocortisone acetate SX, salmeterol xinafoate CMP, chlorophenylamine maleate NaCrGlyc, sodium cromoglycate DMSO, dimethyl-sulfoxide THF, tetrahydrofurane DMF, dimethylformamide. 

MPA = Methylprednisolone acetate, HCA = Hydrocortisone acetate, SX = Salmeta-ol xinafoate, CPM = Chlorphenylamine maleate, HYAFF = Hyaluronic acid ethyl ester, Hy = Hycosinebutylbromide, Thy = Thymopentine, NaCrGlyc = Sodium Cromoglycate... 

Methylprednisolone acetate (MPA) is a synthetic corticosteroid produced as the 6a-methyl derivative of prednisolone. Pharmacological studies of the esters of MPA show that it is rapidly converted to methylprednisolone, the active form. Reversible metabolism of methylpredniso/o to methyl-prednisoMC creates the inactive metabolite. The conversion from the prodrug to the active form of the drug is partially responsible for variations identified in the classification of the duration of MPA activity. High levels of the active product, methylprednisolone, have been identified in synovial fluid within 2 h of MPA injection. Despite the persistence of MPA levels for 5-39 days after injection, the active metabolite was only identifiable for 2-6 days (Auteflage et al 1986). 

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