Mouse heritable translocation test

A positive response in the mouse heritable translocation test indicates that exposure to the test substance results in an increase in the number of translocations observed for at least one test point, or an increase in the number of translocations observed, as a result of heritable gene mutations. 

MHT, Mouse heritable translocation test + 40 ip X 1 Lang Adler (1977)... 

MHT, Mouse heritable translocation test in vivo - 100 po X 1, 8 wk Jorgenson Rushbrook... 

Mammals Cytogenetic damage Mouse Heritable-translocation test Semisterility, confirmed by cytogenetic detection of translocations <9 mo M VH M L... 

As shown in Figure 9-1, a clearly positive result in a germinal mouse test is sufficient to classify a chemical as a mammalian mutagen, regardless of the results in other tests. Such mouse tests are the specific-locus, dominant-skeletal, cataract, and heritable-translocation tests. 

The same chromosome aberration assay described above can be used to detect numerical chromosome changes (i.e., aneuploidy) in bone marrow cells. Chemicals that cause chromosome damage in germ cells can be detected using in vivo assays, either the dominant lethal assay, a test for structural chromosome aberrations in spermatogonia, or a more preferred test, the mouse heritable translocation assay. 

OECD (1986a). Genetic toxicology Mouse heritable translocation assay. OECD Guideline for Testing of Chemicals 485, 1-6. 

Another method of monitoring heritable chromosomal abnormalities is the mouse sex chromosome-loss test. This assay differs from the dominant lethal test and heritable translocation test in that it is thought primarily to measure nondisjunctions. In this assay progeny of treated male and female mice are examined for sex-linked phenotypic differences. 

OECD, 1986f, OECD Test Guideline 485, Genetic Toxicology Mouse Heritable Translocation... 

Mouse visible or eleetrophoretie specifie-locus tests Assays for skeletal and cataract mutations Cytogenetic analy.sis and heritable translocation assays DNA damage and repair in rodent germ cells Dominant lethal assay... 

TABLE 6-1 Results of Tests for Heritable Translocations In the Mouse of 17 Compounds That Produced Translocations or X-linked Lethals in Drosophilaa... 

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