Mouse breathing

Perfluorocarbons (PFCs) came to public notice in the 1960s with the publication of an account of a mouse breathing in this medium. As well as the fact that they dissolve gases (such as oxygen), PFCs have the important property of being easily... 

Three decades have passed since the high solubility of gases in perfluorocarbons was reported with the striking demonstration of a mouse breathing while immersed in perfluorocarbons. Perfluorodecalin (Figure 3.1), which has a low surface tension... 

Vautz, W. Nolte, J. Bufe, A. Baumbach, J.I. Peters, M., Analyses of mouse breath with ion mobility spectrometry a feasibility study, J. Appl. Physiol. 2010,108, 697—704. 

Lydic, R., Douglas, C. L. Baghdoyan, H. A. (2002). Microinjection of neostigmine into the pontine reticular formation of C57BL/6J mouse enhances rapid eye movement sleep and depresses breathing. Sleep 25, 835-41. 

Interestingly, the mouse is much more sensitive to HC1 than the rat [13-16]. In turn, however, the rat works as a good model for a primate, as far as lethality due to HC1 is concerned [17, 18]. This is important because all rodents (mice and rats) are obligate nose breathers, while primates can also breathe through their mouths, and it has been speculated that this would make rodents less sensitive to HC1 than primates [19]. 

Mouse 1 hr Resp 110 (signs of irritation) 470 (difficulty in breathing,... 

Breathing the dust or its absorption through the skin may result in bladder tumors.1-3 LD50 (oral, rat) 309 mg/kg LD50 (oral, mouse) 214 mg/kg.2 Exposure by all routes should be carefully controlled to the lowest possible levels.4... 

Suppression of organ graft rejection. Mouse to rat cardiac transplantation was performed. One group of rats was exposed to 400 ppm CO in air for 2 days following the operation and survived for 50 days. The other group breathed air, and survived only 5-7 days [16]. 

Fig. 1. Buxco whole body plethysmograph for measuring lung function. The mouse is placed in a plexiglas chamber, where it is free to move. A port at the top of the chamber is connected to a nebulizer to allow administration of aerosolized chemicals. A transducer linked to an amplifier monitors the pressure changes within the chamber, which correspond to the animal s breathing rates and depths. These raw data are converted to a value called Penh, which is a measure of BHR. Readout consists of change in Penh over time. An increase in Penh indicates that the mouse is hyperresponsive.

If you didn t cram them so tight, they would survive better, I said. A healthy body needs plenty of fresh air—not recirculated air breathed out by someone else. Experiments have been done that prove that our lungs take part of the air when they inhale so that the blood can be refreshed and revitalized. A mouse will not survive for long under a bell jar, even though not all the air will be gone from it. If so many bodies are breathing so much stale air, they re bound to suffer. ... 

Nothing is known of the biological activity of 251F. The alkaloid fraction from Minyobates bombetes, containing 251F as a major alkaloid, caused severe locomotor difficulties, muscle spasms, and labored breathing, followed by minor convulsions, on injection into a mouse. However, these effects could be due to the pumiliotoxin B and congeners also present in this alkaloid fraction 151). 

Toxicokinetics The distribution and elimination of bromoform resembled those of CHCI3. Bromoform (and organic metabolite) elimination via exhaled breath was greater than that for all other THMs in the rat, but less than that for all other THMs in the mouse. The estimated half-life of bromoform was 0.8 h in rats and 8h in mice. While both oxidative and reductive pathways were involved in bromoform metabolism, oxidative metabolism seems predominant. Bromoform, like DBCM, has a much greater... 

No evidence for formaldehyde-induced effects on the skin has been reported in intermediate-duration inhalation studies with rats, hamsters. Rhesus monkeys, or mice (Appelman et al. 1988 Maronpot et al. 1986 Monticello et al. 1989 Woutersen et al. 1987), or in chronic inhalation studies with rats or mice (Kamata et al. 1997 Kems et al. 1983b), except that the highest concentration used in these studies (40 ppm used in the 13-week mouse study by Maronpot et al. 1986) produced severe clinical signs of toxicity in mice including mouth breathing, ataxia, and loss of skin elasticity . 

Mouse Gd 8-14 Resp 1000 F 1500F (abnormal breathing) Wieretal. 1987... 

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