Motor neuron diseases features

The motor neuron diseases (MND), including amyotrophic lateral sclerosis (ALS), are chronic, progressive illnesses characterized by severely disabling clinical features... 

Li, T.M., Aberman, E. and Swash, M. (1990) Clinical features and associations of 560 cases of motor neuron disease. 7. Neurol. Neurosurg. Psychiatry 53 1043-1045. 

The Scottish Motor Neuron Research Group (1992) The Scottish motor neuron disease register a prospective study of adult onset motor neuron disease in Scotland. Methodology, demography and clinical features of incident cases in 1989. J. Neurol. Neurosurg. Psychiatry 55 536-541. 

Rainier, S., Albers, J.W, Dyck, P.J., et al., 2011. Motor neuron disease due to neuropathy target esterase gene mutation clinical features of the index families. Muscle Nerve 43 (19-25). 

ALS is a neurological disease with damage to motor neurons in the brain and spinal cord. It is characterized by progressive muscle weakness, atrophy, and spasticity. Characteristic neuropathological features include the loss of anterior horn motor... 

Parkinson disease is an age-related neurodegenerative disorder that affects in the US approximately 1 x 10 persons [4]. Pathological features include degeneration of dopaminergic neurons in the substantia nigra coupled with intracytoplasmic aggregates known as Lewy bodies. Neurodegeneration and Lewy bodies can also be found in the locus ceruleus, nucleus basalis, hypothalamus, cortex, motor nuclei. Risk factors are toxins e.g. MPP, which causes a defect of the mitochondrial complex I [4]. 

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