Motilin receptors human

Satoh, M., Sakai, X, Sano, I., Fujikura, K., Kayama, H., Oshima, K., Itoh, Z and Omura, S. (1994). EM-574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum. J. Pharmacol. Exp. Then 271, 574-579. 

The basic functions of the GIT are similar between humans and laboratory animals. However, anatomical, hormonal, and genetic variations are translated into differences in the pharmacologically evoked motility and secretory responses. For example, in human and dog, the GI hormone motilin, which is released firom the upper GIT, exerts prominent stimulatory effects on GIT motility and is involved in the initiation of MMC, whereas its function and receptor gene is lost in rodents... 

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