Mosquitoes lymphatic filariasis

Adult worms that cause human filariasis dwell either in the lymphatics or other tissues. Spread by the bites of infected mosquitoes, lymphatic filariasis (LF) affects -120 million people in sub-Saharan Africa, India, Southeast Asia, the Pacific region, and tropical America. In LF, host reactions to adult worms initially cause lymphatic inflammation manifested by fever, lymphangitis, and... 

Wuchereria bancrofti, a mosquito-transmitted parasite, is the major cause of human lymphatic filariasis in tropic areas. Current estimates suggest that about 120 million people are infected. Infection often leads to microfilaremia without clinical manifestations. The most common clinical presentation of this disease are asymptomatic microfilaremia, filarial fever, and lymphatic obstruction. Ivermectin rapidly reduces microfilaremia concentration in peripheral blood and may inhibit larval development in mosquitoes. Because the drug does not kill adult worms, microfilaremia concentration begins to increase gradually 3-12 months after treatment. 

B. V. Babu et al. Personal-protection measures against mosquitoes A study of practices and costs in adistrict, in the Indian state of Orissa, where malaria and lymphatic filariasis are co-endemic. Ann Trop Med Parasitol, 101, 601, 2007. 

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