Morphine naloxone

Respiratory depression, miosis, hypotension, and coma are signs of morphine overdose. While the IV administration of naloxone reverses the toxic effects of morphine, naloxone has a short duration of action and must be administered repeatedly at 30- to 45minute intervals until morphine is cleared from the body. 

Dopamine Microdialysis in the Nucleus Accumbens During Acute and Chronic Morphine, Naloxone-Precipitated Withdrawal and Clonidine Treatment." Brain Research 566 348-50. 

Fukase, H. et al., Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imi-pramine on morphine withdrawal signs in cynomolgus monkeys, Psychopharmacology, 116, 396,1994. 

Subutex (buprenorphine) and Subuxone (buprenor-phine/naloxone) are legal medications used to treat addiction to opioids. Buprenorphine prevents withdrawal symptoms. Subutex contains only the medicine buprenorphine, while Suboxone contains naloxone as well. When naloxone is injected or taken as a pill, it blocks the effects of medicines and drugs, such as heroin and morphine. Naloxone is added to Suboxone to stop people from injecting, or shooting-up. 

Naloxone is a drug structurally related to the opioid class of analgesics such as morphine. Naloxone has virtually no intrinsic activity but can compete for opioid receptors. By reversibly competing for the p and K opioid receptors in the brain and spinal cord, it can reverse the sedation and respiratory depression associated with an overdose of morphine-like drugs. 

Pothos E, Rada P, Mark GP, Hoebel BG (1991) Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment. Brain Res 566 348-350. 

The ring system in cyclazocine is abbreviated as compared with morphine or the morphinanones nonetheless, the remaining atoms can be superimposed very closely over those of morphine, naloxone, and the agonists shown in Fig. 20(a - d). In other words, crystal structure analyses have shown that all six substances have an almost common geometrical arrangement. In this class of substances, the differences in their activities have to be attributed largely to factors other than conformation. 

Currie, W. Joseph, I. Rawlings, N. Morphine, naloxone and the gonadotrophin surge in ewes. Reprod. Fertil. 1991, 92, 407 14. 

Morphine, naloxone Narcotics CL 0.01-1.00 mg L-1 0.10-1.50 mg L 1 30 Simultaneous time-resolved CL/zone stopping at the detector [145]... 

Effects of morphine, naloxone, naltrexone and. beta.-endorphin on monoamine synthesis in rat brain Ahtee, Liisa Garcia-Sevilla, J. A. Magnusson, T. Carlsson, A. 

H-Lysine accumulation into brain and plasma proteins in male rats treated with morphine, naloxone, or naloxone plus... 

Also analyzed buprenorphine, caffeine, cocaine, codeine, diamorphine, ethylmorphine, h-docaine, methaqualone, morphine, naloxone, noscapine, papaverine, pentazocine, procaine... 

Kobayashi, D. Matsuzawa, T. Sugibayashi, K. Morimoto, Y. Kimura, M. Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model. Pharm.Res., 1994, 11, 96-103 [also atenolol, morphine, naloxone, nitrendipine, vinpocetine]... 

The respiratory depressant effect of meperidine exceeds that of morphine. Naloxone reverses the respiratory depression seen with relative overdoses of meperidine. 

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