Morphine interactions

M . PS-morphine interaction has been determined to have a of -1Q- M (IJ). The results observed in this study suggest that the enkephalin-PS binding is weaker than the interaction of morphine with PS. 

Morphine interacts with the endogenous opioid system... 

Pavone, F., Battaglia, M., Sansone, M. Nifedipine-morphine interaction a further investigation on nociception and locomotor activity in mice, J. Pharm. Pharmacol. 1992, 44, 773-776. 

In both cases, the blood metamfetamine concentration was less than the lethal concentration of 4.5 pg/ml. Morphine concentrations were higher than the non-toxic concentration of 0.3 pg/ml. It is unlikely that morphine was the cause of death, because it would have caused hypothermia instead of hyperthermia. It is more likely that morphine interacted with metamfetamine, increasing the hyperthermic effect that is typical of metamfetamine overdose. This would explain why hyperthermia caused death, despite a non-lethal blood concentration of metamfetamine. 

P-Endorphin. A peptide corresponding to the 31 C-terminal amino acids of P-LPH was first discovered in camel pituitary tissue (10). This substance is P-endorphin, which exerts a potent analgesic effect by binding to cell surface receptors in the central nervous system. The sequence of P-endorphin is well conserved across species for the first 25 N-terminal amino acids. Opiates derived from plant sources, eg, heroin, morphine, opium, etc, exert their actions by interacting with the P-endorphin receptor. On a molar basis, this peptide has approximately five times the potency of morphine. Both P-endorphin and ACTH ate cosecreted from the pituitary gland. Whereas the physiologic importance of P-endorphin release into the systemic circulation is not certain, this molecule clearly has been shown to be an important neurotransmitter within the central nervous system. Endorphin has been invaluable as a research tool, but has not been clinically useful due to the avadabihty of plant-derived opiates. 

Narcotic analgesic. A drug that alleviates pain by interacting with the morphine receptor. 

The existence of further alternative transcripts of MOP was postulated by the observation that in knockout mice with disrupted exon 1, heroin but not morphine was still analgesically active. Based on earlier observations that the antagonist naloxazone blocked morphine-induced antinociception but not morphine-induced respiratory depression, a subdivision of the MOP in pi and p2 was proposed. However, no discrete mRNA for each of these MOP subtypes has been found. It is, however, possible that subtypes of MOPs result from heterodimerization with other opioid receptors or by interaction with other proteins. 

Valerian Valeriana officinalis Restlessness, sleep disorders Rare if used as directed. May interact with the barbiturates (eg, phenobarbital), the benzodiazepines (eg, diazepam) and the opiates, (eg, morphine). 

Yaksh TL, Rudy TA (1977) A dose ratio comparison of the interaction between morphine and cyclazocine with naloxone in rhesus monkeys on the shock titration task. Eur J Pharmacol 46(2) 83-92... 

Hauser KE, Hahn YK, Adjan VV, Zou S, Buch SK, Nath A, Bruce-KeUer AJ, Knapp PE (2008) HlV-1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology. Glia 57 194-206... 

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