Morphine glucuronidation intermediates

MacDougall and Cashman et al. prepared a number of analogs of morphine-6-glucuronide. As such, the amine intermediate 111 was prepared using a phthalimide Mitsunobu reaction. The free phenol was protected as the acetate ester prior to the Mitsimobu reaction since the phenol is more reactive than the vinyl alcohol under the reaction conditions. Other diverse examples employing phthalimide are listed below as well (112-115). - ... 

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