Mood target

However, experience proves that depression can be reversed by drugs that augment serotonergic and noradrenergic transmission (and reinstated by a deficit in the synthesis of these monoamines). These, then seem to be crucial targets that ultimately determine mood. This would explain why, despite numerous neurochemical options for the causes of depression, all antidepressants developed so far (and even those discovered by chance) target these neuronal systems. Whatever the cause of depression, therefore, its relief seems to rest on appropriate secretion of these monoamines. This would be entirely... 

Identification of the Major Cytoprotective Protein bcl-2 as a Target for Mood Stabilizers I 403... 

Wang JF, Young LT. Differential display PCR reveals novel targets for the mood-stabilizing dmg valproate including the molecular chaperone GRP78. Mol Pharmacol 1999 55 521-527. 

Manji, H. K. and Chen, G. PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers. Mol Psych. 7(Suppl 1) S46-56, 2002. 

Peterson CL, Laniel MA (2004) Histones and histone modifications. Curr Biol 14 R546-R551 Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276 36734-36741... 

Histrionic Personaiity Disorder (HPD). HPD has also received remarkably little study, but we can perhaps extrapolate from our experiences with BPD. HPD shares with BPD the target symptom of mood instability. Although medications seldom play a significant role in the treatment of HPD, SSRIs/SNRIs may provide some benefit in alleviating depression as well as in reducing affective lability. 

Noradrenergic projections are involved in the modulation of sleep cycles, appetite, mood, and cognition by targeting the thalamus, limbic structures, and cortex. An increase in noradrenergic function appears to convey some of the therapeutic effect of antidepressants, although the exact mechanisms remain poorly understood (Charney, 1998 Anand and Charney, 2000 Frazer, 2000). 

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