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Mononuclear non-heme iron proteins

The number of known or presumed mononuclear, non-heme iron oxygenases and related enzymes continues to grow. This is due to intensive biochemical research and especially based on sequence data derived from genome research projects i.14). For several of these enzymes structural data are available by now from protein crystallography (12-14). In many of the iron oxygenases the iron is facially bound by two histidines and one carboxylate donor, either glutamic acid or aspartic acid. Thus, the term 2-His-l-carboxylate facial triad has been introduced by L. Que Jr. for this motif (19). [Pg.102]

In the past 15-20 years, several studies have been performed on mononuclear non-heme iron(II) enzymes. Among them, Rieske oxygenases constitute a relevant and paradigmatic example of mononuclear non-heme iron(II) proteins involved in O2 activation reactions. Their efficiency and versatility are even greater than those of the related heme-containing Cyt P450, being able to catalyze stereoselective... [Pg.29]

Although there are three types of active sites in non-heme iron proteins, namely containing one, two, and four iron atoms per center, in the discussion above only tetrameric Fe-S species have been considered. This topic has been treated with some detail because these compounds meet properly the concept of cluster and are therefore clearly within the scope of this book. That is not the case for the di-iron species which form the 2Fe-2S active sites in the ferredoxins nor for the mononuclear center in the rubredoxins. However, in order to get a better understanding of the chemistry of the iron-sulfur proteins, an overview of the chemistry of the 2Fe-2S analogues is also outlined in this Section. [Pg.290]

Proteins in which NO Is a Natural Ligand to Mononuclear Non-Heme Iron... [Pg.261]

Iron-containing proteins are classified as heme, mononuclear non-heme, and binuclear non-heme enzymes. The Fe center... [Pg.1393]

Low-spin ferric iron is conunon in heme and in some iron-sulfiir proteins, but nitrile hydratase is presently the lone example among mononuclear, non-heme, non-iron-sulfur iron proteins [31]. The ferric form of the enzyme is obtained by photolysis of the as-isolated nitric oxide d form. The g-values of the photodissoci-ated ferric protein are 2.27, 2.13, and 1.97, and photointermediates of differing g-values are observed. The relatively narrow linewidths allowed the Fe hyperfine to be measured at (40 MHz), establishing that the g- and iron A-tensors are 45° out of alignment. [Pg.251]


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Heme iron

Heme proteins

Heme-iron proteins

Iron mononuclear

Iron non-heme

Iron protein proteins

Non-heme

Non-heme iron proteins

Non-heme proteins

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