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Monomeric scaffold

EMPl, selected by phage display from random peptide libraries, demonstrates that a dimer of a 20-residue peptide can mimic the function of a monomeric 166-residue protein. In contrast to the minimized Z domain, this selected peptide shares neither the sequence nor the structure of the natural hormone. Thus, there can be a number of ways to solve a molecular recognition problem, and combinatorial methods such as phage display allow us to sort through a multitude of structural scaffolds to discover novel solutions. [Pg.365]

Monomeric hemes possess a mirror plane and are hence achiral (151). Incorporation of the heme macrocycle into the anisotropic protein matrix distorts the heme environment, inducing a circular dichroism spectrum (57, 152, 153). From the design standpoint, the presence of an induced heme CD spectrum qualitatively confirms intimate communication between the heme and the surrounding protein matrix, which indicates the heme is most likely specifically bound. This spectroscopic signature serves as a first indication that the heme resides within the designed protein scaffold and has been used by various groups to... [Pg.433]

Fukuzumi and co-workers described spectroscopic evidence for a ix-rf- ] -peroxo-(Cu )2 species stabilized with a fcidentate nitrogen ligand, but no (catalytic) oxidation behavior towards catechol was noted (a related trinu-clear copper species converted 2,4-di-ferf-butylphenol stoichiometrically towards the biphenol derivative) [224], Stack et al. have described a similar ] -peroxo-(Cu )2 species (28, vide supra) that could be considered a structural and functional model for tyrosinase-activity, as it efficiently reacted with catechol, benzyl alcohol and benzylamine to yield quinone (95%), benzaldehyde (80%) and benzonitrile (70%) [172,173]. This dinuclear per-0X0 species is generated by association of two monomeric copper centers, in contrast to the systems based on dinucleating Ugand scaffolds described above. [Pg.59]

Polymer materials can easily be prepared from HIPEs if one or the other (or both) phases of the emulsion contain monomeric species. This process yields a range of products with widely differing properties. Additionally, as the concentrated emulsion acts as a scaffold or template, the microstructure of the resultant material is determined by the emulsion structure immediately prior to polymerisation. [Pg.163]

Fig. 3.5 Postmodification Dendrimer growth with protected monomeric branching units permits subsequent introduction of functionalities into the scaffold of the dendrimer precursor... Fig. 3.5 Postmodification Dendrimer growth with protected monomeric branching units permits subsequent introduction of functionalities into the scaffold of the dendrimer precursor...
De novo synthesis of dendrimer scaffold necessary a) Convergent synthesis Dendron assembly using appropriately prefunctionalised monomeric building blocks (e.g. AB2FG) starting from the peripheral functional units of the dendrimer to be... [Pg.74]

Table 2.1 Structural parameters for few selected monomeric uncomplexed soluble proteins with disulfide bridges lacking prosthetic groups and scaffolding cation coordination... Table 2.1 Structural parameters for few selected monomeric uncomplexed soluble proteins with disulfide bridges lacking prosthetic groups and scaffolding cation coordination...
Fig. 21 Defining binding site sterics by OSC has permitted isolation of thermodynamically unfavorable monomeric Fe-02 species, as exemplified by the picket fence porphyrins (a). This strategy has also been employed to force non-preferential binding modes, such as end-on r 1 coordination of C02 by U111 coordinated by a bulky tacn scaffold (b)... Fig. 21 Defining binding site sterics by OSC has permitted isolation of thermodynamically unfavorable monomeric Fe-02 species, as exemplified by the picket fence porphyrins (a). This strategy has also been employed to force non-preferential binding modes, such as end-on r 1 coordination of C02 by U111 coordinated by a bulky tacn scaffold (b)...

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Monomeric

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