Monolithic hybrid organic-inorganic

Nanoporous carbon with narrow pore-size distribution can be prepared directly via a one-step nanocasting technique by carbonization of cyclodextrin-silica organic-inorganic hybrid composite.[260] The method consists of preparing a cyclodextrin-templated silica mesophase via soft chemistry, followed by direct carbonization of the occluded cyclodextrins. The nanocasting procedure provides granules (in millimeter scale) or monoliths (in centimeter scale). Cyclodextrins can be employed not only as structuredirecting templates but also as carriers for metal nanoparticle precursors. 

Caffeine, theophylline Beverages CEC organic-inorganic hybrid silica monolith C18-sulfonic groups using a mobile phase containing 25 mM phosphate-borate (pH 8)-acetonitrile (40 60, v/v) UV at 254 run [105]... 

Z. Lin, J. Pang, H. Yang, Z. Cai, L. Zhang and G. Chen, One-pot synthesis of an organic-inorganic hybrid affinity monolithic column for specific capture of glycoproteins, Chem. Commun., 2011, 47(34), 9675-9677. 

Q. Yang, D. Huang, S. Jin, H. Zhou and P. Zhou, One-step synthesis of an organic-inorganic hybrid boronate affinity monolithic column with synergistic co-monomers, Ana sZ, 2013,138(17), 4752-4755. 

Hou C-Y, Ma J-F, Tao D-Y, Shan Y-C, Liang Z, Zhang L-H, et al. Organic—inorganic hybrid silica monolith based immobilized titanium ion affinity chromatography column for analysis of mitochondrial phosphoproteome. J Proteome Res 2010 9 4093-101. 

Scheme 10.14 Scheme ofthe organic-inorganic hybrid silica monolithic matrix formation (a) and trypsin immobilization (b) [128], Source Copyright 2008 American Chemical Society. 

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