Monoclonal immunoassay

A. Lucas, B.D. Hammock, J.M. Van Emon, and R.J. White, Monoclonal immunoassay of triazine herbicides development and implementation, in Immunoassays for Trace Chemical Analysis Monitoring Toxic Chemicals in Humans, Eood, and the Environment., ed. M. Vanderlaan, L.H. Stanker, B.E. Watkins, and D.W Roberts, American Chemical Society, Washington, DC, pp. 59-77 (1991). 

Manclus, J.J., A. Abad, M.Y. Lebedev, et al. 2004. Development of a monoclonal immunoassay selective for chlorinated cyclodiene insecticides. J. Agric. Food Chem. 52 2776-2784. 

Abad, A., M.J. Moreno, and A. Montoya. 1997. A monoclonal immunoassay for carbofuran and its application to the analysis of fruit juices. Anal. Chim. Acta 347 103-110. 

Steimer W (1999) Performance and specificity of monoclonal immunoassays for cyclosporine monitoring how specific is specific Clin Chem 45 371-381... 

S168 Drost, R.H., Schultz, H.U., Maes, R.A.A. and van Rossum, J.M. (1987). A comparative study of a monoclonal immunoassay reagent strip test and high pressure liquid chromatography for theophylline. Clin. Toxicol. 25, 231-241. 

Vermes I, Bonte HA, v d Sluijs Veer G, Schoemaker J. Interpretations of five monoclonal immunoassays of lutropin and follitropin Effects of normalization with WHO standards. Clin Chem 1991 37 415-21. 

A monoclonal immunoassay has been developed for coplanar PCBs (Chiu et al. 1995) and has been carefully evaluated for selectivity and sensitivity. The sensitivity was high by comparison to GC-MS assays in which concentration and cleanup of samples are required, and there was no cross-reaction from 2,3,7,8-tetrachlorod-ibenzo[l,4]dioxin or 2,3,7,8-tetrachlorodibenzofuran. There were certain problems, however, with cross-reactivity among congeners and this was strongly dependent on the solvent in which the assay was carried out. 

---