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Monoclonal antibodies clinical trial case study

Tumor Necrosis Factor There are two types of tumor necrosis factor TNF-a and TNF- 8. Of the two, TNF-a has been studied in more detail. TNF-a is a 157 amino acid polypeptide. It is a mediator of immune regulation, including the activation of macrophages and induction of the proliferation of T cells. Another TNF-a function is its cytotoxic effects on a number of tumor cells. Recent research, however, concentrates on its property in the stimulation of inflammation, particularly in the case of rheumatoid arthritis. Clinical trials are being conducted with drugs to block TNF-a with anti-TNF-a monoclonal antibodies. These antibodies target the excessive levels of TNF-a in the synovial fluid of joints and provide relief to sufferers of rheumatoid arthritis (Exhibit 4.10). [Pg.118]

See other pages where Monoclonal antibodies clinical trial case study is mentioned: [Pg.594]    [Pg.1011]    [Pg.324]    [Pg.291]    [Pg.1011]    [Pg.1410]    [Pg.62]    [Pg.798]    [Pg.3]    [Pg.152]    [Pg.626]   
See also in sourсe #XX -- [ Pg.195 ]



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