Monoclonal antibodies carcinogenicity studies

In a carcinogenicity study, liver cell proliferation in Wistar rats measured using immunostaining with a monoclonal antibody to proliferating cell nuclear antigen in the highest-dose group was maximal at six months of treatment (Yasuhara et al., 1995). 

Enzyme-linked immunosorbent assay (ELISA) is a very useful technique for the specific and sensitive assay of certain compounds, in which suitable antibodies, monoclonal or polyclonal, to the compounds are available. The technique has found particular application m the monitoring of environmental contaminants and toxins, either studying the primarily contaminated materials, e.g., foodstuffs, or body fluids of potentially exposed humans. The technique has been increasingly applied to monitoring the carcinogenic mycotoxins, the aflatoxins. 

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