Monkey safety pharmacology assessments

Murphy DJ, Renninger JP, Gossett KA (1998) A novel method for chronic measurement of pleural pressure in conscious rats. J Pharmacol Toxicol Methods 39(3) 137-141 Murphy DJ, Renninger JP, Coatney RW (2001) A novel method for chronic measurement of respiratory function in the conscious monkey. J Pharmacol Toxicol Methods 46(l) 13-20 Murphy DJ (2002) Assessment of respiratory function in safety pharmacology. Fundam Clin Pharmacol 16(3) 183-196... 

Therefore, in safety pharmacology, the first-tier test used is a neurobehavioural assessment, either in the format of the functional observational battery (FOB) or Irwin test (Moser 1989 LeBel and Foss 1996 Moser et al. 1997 Redfern et al. 2005 Roux et al. 2005 Redfern and Wakefield 2006). Similar assessments have been devised for dogs (Gad and Gad 2003 Tontodonati et al. 2007 Moscardo et al. 2009) and monkeys (Gauvin and Baird 2008 Moscardo et al. 2010 Froget et al. 2012). Where there is specific cause for concern arising from the knowledge of a compound, appropriate single-parameter tests can be incorporated into a repeat-dose toxicity study on a case-by-case basis to address the issue. Examples of suitable tests are listed in Table 3. 

---