Monitoring integrated framework

The new Water Framework Direaive (WFD, Directive 2000/60/EQ marks a change in Community water policy towards a coherent and integrated framework for assessment, monitoring, and management of all surface waters and groundwater based on their ecological and chemical stams. The taigets and principles set out in Directive 91/414/EEC for pesticides were translated into objectives for all waters and will be implemented on a rivet basin scale. With the adoption of the WFD, Community water policy is based firmly on the precautionary principle and the sustainable use of water. 

This framework represents a group eonsensus of the best way to transform, expand, and develop new and existing monitoring programs into an integrated assessment framework. The previous ehapters in this book identified and diseussed many attributes of a sueoessfid indieator (Chapters 2, 3, 4, and 5). The following attributes were identified ... 

European Commission. 2004. Baseline Report on Biomonitoring for Children in the Framework of the European Environment and Health Strategy (COM(2003)338 final). Prepared by the Technical Working Group on Integrated Monitoring. January 9, 2004 [online]. Available http //www.brussels-conference.org/Download/baseline report/BR Biomonitoring final.pdf [accessed June 3, 2005]. 

Committee on Environment and Natural Resources (CENR) (1997). Integrating the Nation s Environmental Monitoring and Research Networks and Programs A Proposed Framework. Office of Science and Technology Policy, Washington, DC. 

The aim of this chapter is to describe the general framework for conducting good clinical practices (GCP)-compliant clinical research. As it is difficult to cover this broad topic in such a short chapter, the authors will focus on those areas that are most discussed, most problematic and most critical to achieving a GCP-compliant clinical study. Thus, there is particular emphasis on ethical issues, source data verification and data integrity, monitoring and safety review, and study medication/device management. 

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