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Moloney murine leukemia virus vectors

The most common retroviral vector is based on the amphotropic Moloney murine leukemia virus (MLV) (31). This system is particularly suitable for efficient in vitro cell transduction the amphotropic MLV has a broad cell tropism, it can be produced at relatively high titers (106—107 iu/mL), and allows for long-term transgene expression because of the viral integration in the host chromosomal DNA. [Pg.339]

There are severable methodologies for expressing siRNAs. One method for stable and controlled expression of siRNAs from the context of the cell is via the use of len-tiviral vectors. Lentiviruses, unlike retroviruses such as Moloney murine leukemia virus (MoMLV), tend to preferentially integrate downstream of active promoters within the active transcriptional unit, potentially limiting their overall oncogenicity... [Pg.576]

See other pages where Moloney murine leukemia virus vectors is mentioned: [Pg.343]    [Pg.319]    [Pg.62]    [Pg.184]    [Pg.35]    [Pg.258]    [Pg.154]    [Pg.811]    [Pg.160]    [Pg.1368]    [Pg.2350]    [Pg.134]    [Pg.423]    [Pg.262]   
See also in sourсe #XX -- [ Pg.154 ]



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Leukemia murine

Leukemia virus

Moloney

Moloney murine leukemia virus

Murine

Vectors murine leukemia viruses

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