MOLGEN

Structure elucidation by various molecule spectroscopic methods (X-PERT, Elyashberg et al. [1997] MOLGEN, Benecke et al. [1997], SPECINFO, Bremser and Grzonka [1991] Canzler and Hellen-brandt [1992] Barth [1993] Neudert and Penk [1996] Schuur [1997]). 

Benecke C, Griiner T, Kerber A, Laue R, Wieland T (1997) MOLecular structure GEN-eration with MOLGEN, new features and future developments. Fresenius J Anal Chem... 

Human Genome Variation Society. Alzheimer Disease Frontotemporal Dementia Mutation Database. Available on line at www.molgen.ua.ac.be/ADMutations/. 

Benecke, C., Griiner, T., Gmnd, R., Hohberger, R., Kerber, A., Laue, R., Wieland, T. Molgen Software. University of Bayreuth, Mathematical Institute www.molgen.de, Bayreuth, Germany, 1997. 

Subsequently, over 20 different APP missense mutations have been identified in 60 families. Interestingly, most of these mutations are located at exons 16 and 17 where the secretase cleavage sites or the APP transmembrane domain are located (Fig. 2). Information regarding APP mutations is available in the NCBI database and the Alzheimer Disease Mutation Database (www.molgen.ua.ac.be/ ADMutations) (Cruts and Van Broeckhoven, 1998). Mutations within APP account for 10-15% of EOFAD (Bird, 2008 Janssen et al., 2003 Raux et al., 2005 Sherrington et al., 1996), appear to be family specific, and do not occur within the... 

Fig. 3 AD3 PSENl structure and mutations. Thus far, at least 123 mutations in the PSENl gene have been described, of which a few are shown. For a more complete list of PSENl mutations, see http //www.molgen.ua.ac.be/ADMutations. TM, transmembrane domains. Scale is approximate...

Alzheimer Disease Mutation Database. May be accessed at molgen http //www.uia.ac.be/ ADMutations/. 

MOLGEN is an expert system developed to model the experimental design activity of scientists in molecnlar genetics. 

Feigenbanm, E.A., et al., A Proposal for Continnation of the MOLGEN Project A Computer Science Application to Molecular Biology, Computer Science Department, Stanford University, Heuristic Programming Project, Technical Report HPP-80-5, April, 1980, 1. 

Rucker, C., Meringer, M. and Kerber, A. (2004) QSPR using MOLGEN-QSPR the example ofhaloalkane boiling points. J. Chem. Inf. Comput. Sci., 44, 2070-2076. 

MOLGEN+, a generator of connectivity isomers and stereoisomers for molecular structure eludication. Anal. Chim. Acta 314,141-147. 

Max Planck Institute for Molecular Genetics, Fabeckstrasse 60-62, 14195 Berlin, Germany e-mail janitz molgen.mpg.de Tel. 4-49-308-4131463... 

CORG http //coig.molgen.mpg.de/ Conserved non-coding sequences... 

SpUceNest http //splicenest.molgen.mpg.de/ View gene splicing from EST... 

SYSYERS http //systers.molgen.mpg.de/ Partition of fam emd superfam... 

All calculations have been performed using MOLGEN-3.1, Benecke C., Gmnd R., Hohberger R. et al.. Anal. Chim. Acta, 1995, 314, 141 147. 

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