Polyethylene glycol, molecular-weight

Figure 4.25 (page 122) shows results obtained on TSK-GEL SW and TSK-GEL PW columns for low molecular weight polyethylene glycol (PEG) oligomers and high molecular weight dextrans. The TSK-GEL G2000PW column successfully resolved components of PEG 200, whereas the TSK-GEL G2000SW column did not (Fig. 4.25A). Therefore, the TSK-GEL G2000PW column would be preferable for this analysis.

Water-miscible, nonvolatile liquids such as low molecular weight polyethylene glycol (PEG-400 and PEG-600) have come into use because of their ability to mix with water readily and accelerate dissolution of dissolved or suspended drugs. 

Somack R, Saifer MG, Williams LD (1991) Preparation of long-acting superoxide dismutase using high molecular weight polyethylene glycol (41,000-72,000 daltons). Free Radic Res Commun 12-13 553-562... 

The water-in-oil-in-water (w/o/w) emulsion method (Figure 11.4) is the predominant method used for encapsulation of biomacromolecules in these microparticles. Protein solution forms the internal water phase of the w/o/w emulsion. Loading efficiency of the microparticles has not been optimal using water or buffer as an internal phase, so water is sometimes substituted with polymeric liquids, such as low molecular weight polyethylene glycol. The primary emulsion is then added to a secondary liquid phase, forming the secondary emulsion. The solvent for the... 

Shin, B.S., et al. 2004. Nasal absorption and pharmacokinetic disposition of salmon calcitonin modified with low molecular weight polyethylene glycol. Chem Pharm Bull 52 957. 

The combination of solid-state ATR-IR and solid-state NMR data supported the conclusion that the presence of crystalline material was responsible for changes in the dissolution profiles of the different lots. The results appear consistent with historical examples of changes in API physical form of solid, high molecular weight, polyethylene glycol dispersion formulations of amorphous indomethacin and griseofulvin (92-95). 

Bentonite may be used with concentrations of up to 30% ethanol or propan-2-ol 50% glycerin 30% propylene glycol or high molecular weight polyethylene glycols. The EINECS number for bentonite is 215-108-5. 

Oral administration of large quantities of polyethylene glycols can have a laxative effect. Therapeutically, up to 4 L of an aqueous mixture of electrolytes and high-molecular-weight polyethylene glycol is consumed by patients undergoing bowel cleansing. 

Alternatively physical separation may be realized by encapsulating the softener in a high-melting matrix such as paraffin wax, high-molecular-weight polyethylene glycol, or fatty acid triglycerides. The softener is released in the liquor as the temperature rises at the end of the wash, when the soil has already been removed. 

Smyth, H., Carpenter, C., Shaffer, C., Xhe toxicity of high molecular weight polyethylene glycols chronic oral and parenteral adminis-... 

---