Molecular surgery approach

If the orifice of an open-cage fullerene encapsulating a guest species can be completely closed while retaining the guest inside, the molecular surgery approach toward the synthesis of endohedral fullerenes is actualized. In 2005, Komatsu and co-workers reported such closure of the orifice of H2 56 by a four-step sequence of... 

A parallel approach for subwavelength molecular surgery using gene-spedfic positioned metal nanopartide as laser light antennas. Nano Letters, 7, 247-53. 

Modem cancer therapy has been primarily dependent upon surgery, radiotherapy, chemotherapy, and hormonal therapy (72) (see Chemotherapeutics,anticancer Hormones Radiopharmaceuticals). Chemotherapeutic agents maybe able to retard the rate of growth, but are unable to eradicate the entire population of neoplastic cells without significant destmction of normal host tissue. This serious side effect limits general use. More recentiy, the immunotherapeutic approach to cancer has involved modification and exploitation of the cellular and molecular mechanisms in host defense, regulation of tissue proliferation, tissue differentiation, and tissue survival. The results have been more than encouraging. 

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