Guests hydrophobic

Figure 4.5. Expansion of a micelle by inclusion of a hydrophobic guest into the hydrophobic interior of the micelles. The guest is hydrophobic, and thus does not like heing in water. The interior of the micelle is similarly water-repellent, and thus is a much more comfortahle environment for the guest. The incorporation of the guest into the centre of the micelle causes an expansion, which in turn leads to larger pores in the resultant material.

Figure 16.13 Example of a dendritic cyclophane used by Diederich etal. [172] as a receptor for hydrophobic guest molecules...

The results may provide a guidepost for designing hybrid assemblies which are capable of performing effective binding of anionic and hydrophobic guests that are not incorporated into the anionic bilayer membrane itself macrocyclic... 

The hydrophobic cavity provided by the octopus cyclophane is significantly flexible, and capable of performing molecular recognition toward hydrophobic guest molecules of various bulkiness through the induced-fit mechanism, not only in aqueous solution but in the bilayer membrane formed with a synthetic peptide lipid. However, such a flexible hydrophobic cavity seems to be unfavorable for size-sensitive molecular discrimination. 

The inclusions and dynamics of various molecules into cyclodextrins, cyclic oligosaccharides generally serving as a hydrophilic cover for the hydrophobic guest, and formations of... 

Fig. 17. Model of the clathrate structure of the water in clathrates I. The centre of the hole is occupied by hydrophobic guest molecules in gas-hydrates (model of the iceberg formation in aqueous solution )...

It was found that efficient inclusion crystallization can be accomplished simply by mixing powdered crystalline host and a hydrophobic guest compound in hexane or water. By using the inclusion crystallization in suspension media, very efficient optical resolution method was established. Furthermore, when inclusion complexation between chiral host and rac-guest in the solid state is combined with a distillation procedure, optical resolution can easily be accomplished by the fractional distillation procedure. 

A unique dendrimer series possessing an all-hydrocarbon interior and up to 36 surface carboxylic acid groups has exhibited very interesting unimolecular micelle properties. These products have been shown to form host-guest complexes with various hydrophobic guest molecules. Newkome refers to these products as micellanes [137, 138]. 

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