Molecular networks, intracellular

Small Molecules That Affect Intracellular Molecular Networks... 

This chapter provides a technical overview of microarrays, including information on array formats, production and use of microarrays for interrogating various molecular species—DNA, RNA, and proteins—and analysis of data. The challenges in experimental design to maximize microarray data quality, and the use of microarrays in understanding intracellular molecular networks as well as in drug discovery and development, are also discussed. 

A prerequisite for this model is the existence of both external and internal gates, i.e., protein domains that are capable of occluding access to the substrate binding site from the extracellular and intracellular environment, respectively. Little is known about such domains in this family of transporters. The molecular mechanisms governing the cooperative function of the putative gating domains also remain unknown. It could be predicted, however, that stabilization of the transporter in the outward-facing conformation in the absence of substrate but in the presence of Na+ requires a network of con-... 

Various information networks such as gene, intercellular, intracellular, sensory, and brain information networks are implemented in biological systems. The information transduction, conduction, and retreaval functions are integrated in these bioinformation networks. Every bioinformation network is totally consisted of organic molecules including protein. A keen interest has been focused on the molecular mechanisms of the information transduction by the biomolecular assemblies because of their excellent selectivity and sensitivity. This chapter concerns protein molecular... 

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