Molecular mechanism, hydrotropic

The analysis of hydrotropic action is conveniently divided into two parts (1) The isotropic llquld/llquld crystalline equilibrium between essential phases and (2) The molecular mechanism for the Influence of the hydrotrope on the equilibrium. [Pg.108]

The molecular mechanism behind the destabilization of liquid crystals was subsequently clarified [25], The specific disordering promoted by the hydrotrope in the water-surfactant-oily liquid crystal was first determined, followed by an investigation into the conformation of the diacid molecule itself [92],... [Pg.32]

Some rationalization of drug complexation is possible by the use of Hiickel frontier molecular orbitals [300]. These confirm 7i-donor-7c-acceptor mechanisms for the interactions with niacinamide of the compounds shown below in aqueous solution. Phase-solubility diagrams all showed positive deviations from linearity, behaviour attributed to first- and second-order interactions between the solute (S) and the hydrotrope (H) ... [Pg.374]

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