Molecular LEGO

Scheme 10. The molecular LEGO set employed in the synthesis of kohnkene 43 [21, 112]. Both the thermally-promoted and high pressure-promoted Diels-Alder reactions proceed with the same remarkable treble diastereoselectivities. The clock-face shown in the middle of structure 43 provides a convenient frame of reference for the discussion of structural features in the macropolycycle...

The Incorporation of [a,c]-Fusion into the Molecular LEGO Set — The Synthesis of Angular Belts and Cages... 

Scheme 21. The molecular LEGO set used for the synthesis of the angular [12]cyclacene derivative 78. The angular nature of the bisdienophile 74 also results in the production of the acyclic aduct 79 during the high pressure-promoted cycloaddition process...

Scheme 24. The molecular LEGO set used for the synthesis [142] of the molecular cage compound — trinacrene 85...

Another example of a repetitive methodology is the stereoregular Diels-Alder oligomerization procedure reported in 1992 by Stoddart et al.7 (Scheme 4). With this molecular LEGO strategy, he built several cycloacenes by periodical repetition of the same procedures. 

Cohen P (2000) The regulation of protein function by multisite phosphorylation-a 25 year update. Trends Biochem Sci 25 596-601 Heroes E, Lesage B, Gornemann Jet al (2013) The PPl binding code a molecular-lego strategy that governs specificity. FEBS J 280(2) 584-595... 

Reference was also made at the US/Japan Joint Seminar in Miami to the concept of molecular lego by Professor Richard D. Gandour from Louisiana State Univeristy. 

Fig. 8.6 The molecular Lego approach applied to the scaffold of P450 BM3 a to generate a P450 catalytic domain electrochemically accessible through the fusion with the electron transfer protein flavodoxin b to solubilize the human membrane-bound P450 2E1 by fusion with select-...

Molecular Lego An approach for the design of molecular assemblies of P450 enzymes and redox partners for nanobiotechnology [149, 150],... 

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