Multisite phosphorylation

Cohen, P. (2000). The regulation of protein function by multisite phosphorylation a 25 year update. Trends Biochem Sci 25, 596-601. 

K., and Koizumi, S., Sequential cis/trans autophosphorylation in TrkB tyrosine kinase. Biochemistry 36,2694-2700,1997 Cohen, R, The regulation of protein function by multisite phosphorylation — a 25 year update. Trends in Biochem. Sci. 25, 596-601, 2000 Wick, MJ., Ramos, F.J., Chen,... 

Behar M, Hao N, Dohlman HG, Elston TC. Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways. Biophys. J. 2646 93 806-821. Markevich NI, Hoek JB, Kholodenko BN. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. CeU Biol. 2004 164 353-359. 

Regulation of glycogen synthase by multisite phosphorylation. The location of phosphorylation sites ( ) and the protein kinases that phosphorylate at these sites (boxes) are shown. Phosphorylations occur only at N- and C-terminal regions of the enzymes, as indicated by CB-N and CB-C, respectively. The single-letter abbreviations for amino acids are used (see Chapter 2). cAMP-PK = cyclic AMP-dependent protein kinase CAM-MPK = Ca +/calmodulin-dependent multiprotein kinase PhK = phosphorylase kinase GSK = glycogen synthase kinase CK = casein kinase NIO-PK = A novel protein kinase. [Reproduced with permission from P. Cohen, Protein phosphorylation and hormone action. Proc. R. Soc. Lonrf. (Biol.) 234, 115(1988).]... 

Cohen P (2000) The regulation of protein function by multisite phosphorylation-a 25 year update. Trends Biochem Sci 25 596-601 Heroes E, Lesage B, Gornemann Jet al (2013) The PPl binding code a molecular-lego strategy that governs specificity. FEBS J 280(2) 584-595... 

Countaway, J.L. et al.. Multisite phosphorylation of the epidermal growth factor receptor use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation, J. Biol Chem., 265,3407,1990. 

Cateau, H., Tanaka, S. (2002). Kinetic Analysis of Multisite Phosphorylation Using Analytic Solutions to Michaelis-Menten Equation. J. Theor. Biol. 217,1-14. 

Zappacosta, F., Collingwood, T.S., Huddleston, M.J., and Annan, R.S. (2006) A quantitative results-driven approach to analyzing multisite protein phosphorylation. Mol. Cell. Proteomics 5(11), 2019-2030. 

Roach, P.J. (1991) Multisite and hierarchal protein phosphorylation. J. Biol. Chem. 266, 14,139-14,142. 

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