Molecular interactions binding site formation

The X-ray structures of the bci complexes from bovine heart, chicken heart, and the yeast Saccharomyces cerevisiae have been determined at 3.0 - 2.3 A resolution [3-6] therefore, it is possible to explore the interaction between the complex and quinones and inhibitors at molecular level. First, we will give an overview of essential structural features of the bci complex. As the non-catalytic subunits are not involved in the coordination of the redox centers or the formation of quinone binding sites, only the structure of the three eatalytic subunits will be discussed in the following section (Figure 3) for a more detailed description see [19]. In order to avoid confusion, the residue numbering of the yeast bci complex will be used even if other organisms have been studied. 

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