Molecular genetics rearrangements

Systematic FISH mapping of disease-associated balanced chromosome rearrangements (Debars) H.-H. Ropers, MPI for Molecular Genetics, Berlin... 

Molecular Genetic Basis for Immunoglobulin-Gene Rearrangements... 

Through the combined effects of mutations, gene duplication, and genetic rearrangement, organisms can develop new proteins. The process of organismal evolution is largely a consequence of this molecular evolution of proteins. 

Thorough biochemical analysis of carotenoid biosynthesis, classical genetics, and more recently molecular genetics resulted in the elucidation of the main routes for the synthesis of acyclic and cyclic carotenoids at a molecular level (Sandmann 2001). Little is known, however, about the biosynthesis of carotenoids containing additional modifications of the end groups, the polyene chain, the methyl groups, or molecular rearrangements that contribute to the tremendous structural diversity of carotenoids. At present, hundreds of individual carotenoids have been characterized (Britton et al. 1998), and novel carotenoids continue to be isolated. All carotenoids are derived from the isoprenoid or terpenoid pathway. 

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