Molecular Genetics project

Although molecular genetics was rapidly increasing in complexity at the time, the Human Genome Project (HGP) that was born in the late 1980s... 

Due to the further development of methodologies and technical equipment, the focus of molecular genetics shifted from single genes to whole genomes. The systematic analysis of complete genomes - the Human Genome Project - as well... 

The connections between radioactive science and industry, prefiguring those between nuclear science and industry, were well in place long before the Manhattan Project, a conclusion that echoes Nicolas Rasmussen s remarks on molecular genetics not being the first life science to become biotechnology (see his paper in... 

Bacteriophage X is a genetically complex and extensively studied virus of E. coli. Because it has been the object of molecular genetic research, it was investigated and developed as a vector. The DNA of phage X, in the form in which it is isolated from the phage particle, is a linear duplex molecule of about 45.5 kb pairs. The entire DNA sequence has been determined (SI). At each end are short, single-stranded 5 projections of 12 nucleotides that are complementary in sequence and by which the DNA adopts a circular structure when it is injected into the host cell i.e., X DNA naturally has cohesive termini that associate to form the cos site. 

Cook-Deegan, R. M., TheGenesis of the Human Genome Project, Molecular Genetic Medicine, Volume 1, T. Friedmann (ed.)(San Diego, CA Academic Press, 1991). 

In 1966,1 also started a long-term project on the molecular genetics of yeast mitochondria. This model system provided important results as far as both the organization and the evolution of eukaryotic genomes are concerned. These findings will be briefly presented and discussed in Part 2 of this book. In the 1960 s we also performed a series of investigations on the physical chemistry of DNA (see, for instance, Froelich et al., 1963 Freund and Bernardi, 1963) and on transforming DNA from Haemophilus influenzae (Chevallier and Bernardi, 1965, 1968 Bernardi and Bach, 1968 Kopecka et al., 1973). 

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