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Molecular genetics gene knockout

In summary, the application of molecular genetic techniques has revolutionized our understanding of Na channel structure and function. With recent developments in high expression cell-specific gene delivery systems, inducible knockouts, and the complete sequencing of the mouse and human genomes, it... [Pg.165]

The last decade has provided new molecular and genetic tools for the analysis of changes in the dopamine turnover, particularly in the generation of strains of knockout mice that are deficient in various aspects of dopamine neurone development, in the cellular machinery for dopamine neurotransmission, or in other genes associated with parkinsonism in man. As several good recent reviews are available (Jankowsky et al., 2002 Eells, 2003), the present account will focus on the behavioral phenotypes associated with genetic manipulation of dopamine systems of the forebrain. [Pg.275]

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See also in sourсe #XX -- [ Pg.77 , Pg.78 , Pg.78 ]



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Genes knockout

Genetics molecular

Knockout

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