Moisture content particle morphology

If the drug is insufficiently soluble to allow delivery of the required dose as a solution (the maximum delivered dose for each nostril is 200 p,L), then a suspension formulation will be required. There are additional issues for suspension products, for example crystal growth, physical stability, resuspension, homogeneity and dose uniformity. Suspension products will also require information on density, particle size distribution, particle morphology, solvates and hydrates, polymorphs, amorphous forms, moisture and/or residual solvent content and microbial quality (sterile filtration of the bulk liquid during manufacture is not feasible). 

The results of 3D steady-state numerical predictions of particle trajectories colored by particle surface temperatures, moisture contents, and particle morphological states are shown in Figures 10.13 through 10.15. These figures also demonstrate the comparison with 2D axisymmetric calculations [46]. 

The yield and the moisture content were obtained by weighing of the product. The particle morphology was investigated by electron microscopy and laser diffraction is applied to determine der particle size distribution. 

Berggren J, Alderbom G. Effect of polymer content and molecular weight on the morphology and heat- and moisture-induced transformations of spray-dried composite particles of amorphous lactose and poly(vinylpyrrolidone). Pharm Res 2003 20 1039-1046. 

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