Modulation of cell growth

However, recently, several other non-redox mechanisms have been implicated in the modulation of cell growth by carotenoids, which include the direct modulation of the expression of proteins and transcription factors involved in cell proliferation, differentiation and apoptosis. 

Over the years it has been found that a number of PUFAs can promote the growth of many cell lines when added to cultures at low concentrations [42], Above 20-30 iM however inhibitory effects are often observed [43]. In terms of the modulation of cell growth and differentiation there have been a number... 

Zoidl G, Blass-Kampmann S, D Urso D, Schmalen-bach C, MuUer HW. Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells modulation of cell growth. EMBO J 1995 14 1122-8. 

Recently, glycosphingolipids and sphingomyelin attract attention postulated as modulators of cell growth and cell differentiation [12,13]. 

The evolving understanding of the complex interplay between dioxin-like compounds and hormones and other modulators of cell growth and differentiation continues to complicate more precise determinations of cancer hazard and risk. 

Hakomori S, Igarashi Y. Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. Adv Lipid Res. 1993 25 147-162. 

Bremer EG, Hakomori S, Bowen-Pope DF, Raines EW, Ross R Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation. J. Biol. Chem. 1984 259 6818-6825. 

Bremer EG, Schlessinger J, Hakomori S Ganglioside-mediated modulation of cell growth Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 1986 261 2434-2440. 

Other, more general effects of insulin on cellular function include stimulation of cell growth (increase in DNA and protein synthesis), inhibition of apoptosis, and modulation of ion-channel activity. 

Along the mung bean hypocotyl, the cell wall plasticity represents the limiting factor of cell growth potentials. Pectin molecules, known to control local cell wall pH s and to modulate phenolic cross-linking owing to the number of free acidic domains, were investigated. 

Several ILs, particularly those capable of modulating transformed cell growth, as well as those exhibiting immunostimulatory properties, enjoy significant clinical interest. As with other cytokines, the advent of recombinant DNA technology facilitates production of these molecules in quantities sufficient to meet actual/potential medical needs. 

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