Modified paradigm

Evidence supporting the original paradigm of lignin in wood as a random, three-dimensional network polymer is reviewed. More recent results which do not fit this simple picture are discussed. A modified paradigm is proposed in which lignin in wood is comprised of several types of network which differ from each other both ultrastructurally and chemically. When wood is deligni-fied, the properties of the macromolecules made soluble reflect the properties of the network from which they are derived. 

Sayeh, E., and Uetrecht, J.P., Factors that modify penicillamine-induced autoimmunity in Brown Norway rats Failure of the Thl/Th2 paradigm. Toxicology, 163, 195, 2001. 

To establish new paradigms or to modify the Thl/Th2 paradigm, it is important to consider the function of the new subsets Treg cells control or... 

Indiplon is rapidly absorbed (1-2 h) and eliminated (ti/2 =1.3 h). In-vitro studies on indiplon show two major metabolites A-demethylation due to CYP3A4/5 and Ai-deacetylation by carboxylesterases. Its short half-hfe has enabled the development of two dosing paradigms with different formulations (1) an immediate release formulation to improve sleep initiation and for dosing in the middle of the night, and (2) a modified release formulation, which provides for immediate release and sustained release of the drug to help with sleep initiation, duration, maintenance, and sleep quality (Neubauer,... 

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