Models for Protein Release from Matrices

MECHANISMS AND MODELS FOR PROTEIN RELEASE FROM MATRICES 

F urel. Schematic view of a protetn/hydrophobic polymer matrix system, (a) Cross-sectional views of matrices at two different loadings. At higher loadings, connected clusters of pores are formed, providing continuous paths for diffusion to the surface, (b) Typical pores within the matrix are enlarged. Large pores (diameters of 100-400//m) are connect by smaller channels (diameters of l-10//m). The constricted diffusional pathway contributes significantly to the slowness of release. 

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