Model for Carcinogenic Risk Assessment

The available evidence indicates that Druckrey s equation [Eq. (3.10)] with n 1 can serve as a regulatory basis for risk assessment of genotoxic and nongenotoxic carcinogens. Carlborg (1981) pointed out that this equation is implied by a Weibull model for dose-response functions in carcinogenesis, as follows. The simple form of the Weibull model is 

The extended form of the WeibuU model includes the age of the animals at death (t)  

The authors gratefully acknowledge the critical review of the manuscript by Professor Volker Wunderlich of the Max Delbriick Center for Molecular Medicine (MDC), Berlin. Editorial help from Dr. Derek J. Knight and Duncan Harris of the Department of Registration Services at SafePharm Laboratories Ltd. is acknowledged. 

and Purchase, I. F. (1992). Nongenotoxic carcinogens An extension of the perspective provided by Perera. Environ Health Perspect 98, 223-226. 

Bauer-Hofmann, R., Buchmann, A., Wright, A. S., and Schwarz, M. (1990). Mutations in the Ha-ras proto-oncogene in spontaneous and chemically induced liver tumours of the CFl mouse. Carcinogenesis 11, 1875-1877. 

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