Modas

Moda, M.C. Explosive Property Data, University of California Press, Berkeley, California 1980... 

Lawson, D. M., Williams, C. E., Mitchenall, L. A., and Pau, R. N. (1998). Ligand size is a major determinant of specificity in periplasmic oxyanion-binding proteins the 1.2 A resolution crystal structure of Azotobacter vinelandii ModA. Structure 6, 1529-1539. 

In 2007, Moda et al. [60] developed a set of Hologram QSAR models for a much smaller data set of 250 molecules in comparison to the above-discussed models. They found that using all atoms, bonds, connections, and chirality to define molecular fragments led to a set of encouraging models and the best one was achieved when the fragment size was from 4 to 7, which had q2 of 0.7 and r2 of 0.93. This model was too good to be true since the standard error was only 7.60, much smaller than the average experimental error, which is 14.5 based on 367 experimental data [55]. 

It is obvious that the available prediction models cannot give reliable estimations for oral bioavailability. The prediction errors were typically larger than 20% except the Moda s model, for which the data set only had 250 molecules in contrast, all other models utilized a much larger data set. 

Recently, hologram quantitative structure-activity relationship (HQSAR) was conducted by Moda et al. [63] on a series of structurally diverse molecules with known PPB. The best statistical model (n — 250, r2 = 0.91, and q2 — 0.72) was used to predict the PPB of 62 test set compounds, and the predicted values were in good agreement with the experimental results (ntest —62, q2 — 0.86, RMSEtest = 12%). It is indicated that this model used a much smaller data set than the VolSurf and Wang7s models. 

Generally speaking, PPB is an easier ADME-Tox property to be modeled in comparison to HIA and bioavailability. The prediction errors were only marginally larger than the experimental errors (Wang s model and Moda s model). When PPB is expressed as log Kt SA, the RMSEs were about 0.35 to 0.45. 

Moda, T.L., Montanari, C.A., Andricopulo, A.D. Hologram QSAR model for the prediction of human oral bioavailability. Bioorg. Med. Chem. 2007, 15, 7738-45. 

Multiple Objective Decision Analysis (MODA) designs the most preferred alternative within a (usually continuous) solution space using a mathematical programming structure to optimize the level of a set of quantifiable objectives. 

The assessment/ranking of potential or existing production sites clearly falls into the realms of MADA. Consequently, this work does not consider MODA tools. For a discussion of MODA methods and further references the reader is referred to Steuer (1986) and Hwang and Masud (1979). 

MODA Technology Partners LONZA GROUP Mohawk Carpet LLC MOHAWK INDUSTRIES INC MonOxbar CONSTAR INTERNATIONAL INC Moorgard BENJAMIN MOORE CO Mosaic Canada ULC CANPOTEX LIMITED Mosaic Crop Nutrition, LLC POTASH CORPORATION OF SASKATCHEWAN INC Mosaic Potash Esterhazy, LP POTASH CORPORATION OF SASKATCHEWAN INC Motiva Enterprises LLC SHELL OIL CO M-tec COMPAGNIE DE SAINT-GOBAIN SA... 

PZero Moda S.r.l. PIRELLI C SPA Qapco TOTAL PETROCHEMICALS Qatar Chemical Company (Q-Chem) QATAR PETROLEUM... 

JANAF Thermochemicals Tables, Editor Stull, D. und Prophet, H., National Standard Reference Data Series, National Bureau of Standards, Midland, Michigan, USA 2. Edition 1971, Updates 1974-1982 Moda, M. C. Explosive Property Data, University of California Press, Berkeley, California 1980... 

Figure 2.13 Relationship between A and Z for nuclides of the series A(modA) = 0...

An affoctivo diractioaol m oati paraonnal tniae can ba moda Pipa Gap aMlo oa only oaa... 

Hara K, Okamoto M, Aki T, Yagita H, Tanaka H, Mizukami Y, Nakamura H, To-moda A, Hamasaki N, Kang D (2005) Mol Cancer Ther 4 1121... 

Oberfladien- material Charaktcrisiening der Obcrflache Tempe- ratur Gas Akkom- moda- tions- koeffi- zient Beobachter... 

CA Hlavka and DL Peterson. Analysis of Forest Foliage Spectra Using a Multivariate MEflme,ModA.NearInfraredSpectrosc. 5 167-173, 1997. 

Livia Maria Rosatto Moda Department of Cell and Molecular Biology, Faculdade de Medicina deRibeirdo Preto, University ofSdo Paulo, Ribeirdo Preto, SP, Brazil Su-Yau Mao Gaithersburg, MD, USA... 

Ricardo Guelerman Pinheiro Ramos, Luciana Claudia Herculano Machado, and Livia Maria Rosatto Moda... 

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