Ligand size

Leciejewicz J, Alcock NW, Kemp TJ (1995) Carboxylato Complexes of The Uranyl Ion Effects of Ligand Size and Coordinat. Geometry Upon Molecular and Crystal Structure. 82 43-84... 

Perform random mutations on each ligand by altering atom types. Mutations do not affect ligand sizes and conformations. During simulated... 

The tris(trimethylsilyl)silyl ligands can be easily modified by reactions with silyl chlorides, as shown with a series of phenylated species Mes Ph SiCl (n = 0-3). Furthermore, triisopropyl, thexyldimethylsilyl, or tert-butyldimethylsilyl substitution are all easily possible.190 The crystallographic characterization of some of the alkali metal derivatives indicates a direct correlation between ligand size and resulting structural parameters. 

Solv=MeOH, EtOH and PrOH), and l,4-bis(4-pyridyl-butadiyne) (bpb, n= 0.5, Solv=MeOH). Like the btr derivative, compressed [FeN6] pseudo-octahedral sites define the knots of the square- or rhombus-shaped windows, which constitute the layered grid structure of the three compounds. Stacking of these layers in the crystal defines their most important structural differences, which are determined by the ligand size and crystal packing efficiency. In principle, the 2D grids are organised in a fashion similar to that described for the [Fe(btr)2(NCX)2]-H20 system the parallel layers are alternated so that the iron atoms of one layer lie vertically above and below the centres of the squares formed by the iron atoms of the adjacent layers. 

Lawson, D. M., Williams, C. E., Mitchenall, L. A., and Pau, R. N. (1998). Ligand size is a major determinant of specificity in periplasmic oxyanion-binding proteins the 1.2 A resolution crystal structure of Azotobacter vinelandii ModA. Structure 6, 1529-1539. 

L. Sacksteder, J. N. Demas, and B. A. DeGraff, Design of oxygen sensors based on quenching of luminescent metal complexes Effect of ligand size and heterogeneity, Anal. Chem. (submitted). 

A number of ACE assays dealing with the characterization of interactions between cyclodextrines as auxiliary substances and drugs have been presented. Other authors put more emphasis on the description of separation phenomenona by determination of binding constants. Model substances such as phenols are often used to examine the influence of ligand size and substitution as well as to evaluate the mathematical approaches for the calculation of binding constants. 

Since GRIFFIN requires sequence and ligand size as input information, we apply this program to all GPCR sequences... 

The key to the stabilization of two-coordinate monomeric stractures is obviously ligand size however, the metal also plays a role because in the case of zinc and cadmium the tendency to associate is more marked than it is for mercury. An example is provided by the monomeric strucmre observed for [Hg N(SiMe3)Ph 2],... 

Coupez, B., Boehme, C., Wipff, G. 2002. Interaction of bifunctional carbonyl and phos-phoryl ligands with M3+ lanthanide cations How strong is the bidentate effect The role of ligand size and counterions investigated by quantum mechanics. Phys. Chem. 4 5716-5729. 

A good way to compare ligands with different affinities/potencies and molecular weights is to normalize the affinity/potency with the ligand size.19,101 This is called ligand efficiency (LE), with the following definition 1101... 

Steric Effects Ligand Size, Flexibility, and Symmetry... 

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