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MNNG

Assume that the reaction occurs between the two uncharged species, MNNG and Am, with a rate constant kN. Express ks as a function of tN, K m, Kan, and [H. Sketch the anticipated pH profile. Actually, this situation is further complicated because kN, although constant over some pH range, shows a further variation that can be attributed to an acidic intermediate. Derive an expression for kN as a function of [H + ] from the scheme shown, denoting the acid ionization constant of the steady-state intermediate as Knl. [Pg.153]

The mutagenic activity of the extracts was assayed using Salmonella typhimurium strain TA 1535, as described by McCann et al. (58). Ten ul of fish extract were spot-tested without addition of an S9-enzyme preparation (57). MNNG (20 ug/plate) was used as a positive control. [Pg.309]

The incomplete (less differentiated) foci of metaplasia surround foci of cancer, suggesting progressive loss of differentiation (16, 19). High nitrite levels in the gastric cavity have been associated with acceleration of the gastric cancer induction with MNNG in experimental animals (26). Gastric cancer has been induced in experimental animals with products derived from nitro-sated fish (32). [Pg.327]

Tab. 13.2 Cell cycle of MNNG/HOS cells treated with either MTX or MTX-LDH. Tab. 13.2 Cell cycle of MNNG/HOS cells treated with either MTX or MTX-LDH.
MK-447, 2-aminomethyl-4-tert-butyl-6-iodophenol MNNG, 1 -methyl-3-nitro-1 -nitrosoguanidine MPO, myeloperoxide... [Pg.31]

PLC/PRF/5-A7-1-13-2-GPRT MNNG 8-AG 5-6x10 GPRT defect 1-2x10 ... [Pg.214]

MNNG ir male/female CD-Fischer rat LCA/tauro-DCA Narisawa et al., 1974 ... [Pg.87]

AOM, azoxymethane MNNG, JV-methyl-JV -nitro-JV-mtrosoguamdine DMH, 1,2-dimethyl-hydrazine MNU, W-methyl-W-nitrosourea PhIP, 2-amino-l-methyl-6-phenylimidazole[4,5-b] pyridine sc, subcutaneous ip, intra-peritoneal ir, intra-rectal po, by mouth. [Pg.87]

Figure 6. Chromosome aberrations induced in human fibroblasts by nitroso-guanidine (MNNG) (redrawn from Ref. S)... Figure 6. Chromosome aberrations induced in human fibroblasts by nitroso-guanidine (MNNG) (redrawn from Ref. S)...
Human fitvoblasts, 8 AG Human diploid lymphoblasts, S-TG. MNNG quadratic Jacobs and DeMars, 1978... [Pg.83]

Kim, D. J., B. W. Ahn, B. S. Han, and H. Tsuda. 1997. Potential preventive effects of Chelidonium majis L. (Papaveraceae) herb extract on glandular stomach tumor development in rats treated with V-methyl-V -nitro-V nitrosoguanidine (MNNG) and hypertonic sodium chloride. Cancer Lett. 112 203-208. [Pg.335]

Figure 6.26 The dose-response patterns for teratogenicity caused by the cytotoxic agent MNNG. Pregnant mice were treated on day 11 with MNNG. Abbreviation MNNG, /V-methyl-W-nitro-W-nitrosoguanidine. Source From Ref. 9. Figure 6.26 The dose-response patterns for teratogenicity caused by the cytotoxic agent MNNG. Pregnant mice were treated on day 11 with MNNG. Abbreviation MNNG, /V-methyl-W-nitro-W-nitrosoguanidine. Source From Ref. 9.
MNNG N-methyl-N -nitro-N-nitrosoguanidine. monomer single subunit of a compound such as a protein, monomorphic with one form. [Pg.417]

See other pages where MNNG is mentioned: [Pg.401]    [Pg.99]    [Pg.153]    [Pg.153]    [Pg.153]    [Pg.128]    [Pg.307]    [Pg.310]    [Pg.313]    [Pg.314]    [Pg.321]    [Pg.720]    [Pg.87]    [Pg.87]    [Pg.87]    [Pg.111]    [Pg.526]    [Pg.550]    [Pg.83]    [Pg.83]    [Pg.84]    [Pg.95]    [Pg.96]    [Pg.333]    [Pg.721]    [Pg.192]    [Pg.192]    [Pg.224]    [Pg.243]    [Pg.244]    [Pg.276]    [Pg.350]    [Pg.351]    [Pg.351]    [Pg.351]   
See also in sourсe #XX -- [ Pg.302 ]

See also in sourсe #XX -- [ Pg.1197 ]



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1 -Methyl-3-nitro-1 -nitrosoguanidine MNNG)

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