Mixture-based synthetic combinatorial

Houghten RA. Parallel array and mixture-based synthetic combinatorial chemistry tools for the next millennium. 

Houghten, R.A., Parallel array and mixture-based synthetic combinatorial chemistry tools for the next millennium, Anna. Rev. Pharmacol. Toxicol., 2000, 40, 273-282. 

Appel, J.R., Johnson, )., Narayanan, V.L., and Houghten, R.A. Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays. Mol Div. 1999, 4, 91-102. 

Preparation of Mixture-Based Synthetic Combinatorial Libraries... 

Two major techniques are generally employed in solid-phase chemistry to generate mixture-based synthetic combinatorial libraries (SCL) of millions of compounds. Multiple functionalities at diverse positions within the library are incorporated either by mixing multiple resins or by using mixtures of incoming reagents. 

Generally, when developing a mixture-based synthetic combinatorial library, reaction conditions for all the steps in the reaction scheme need to be optimized to achieve the widest possible breadth of diversity and... 

Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, 46. Brunner D, Schneider J. Strategies for the use of mixture-based synthetic combinatorial libraries scaffold ranking, direct testing 47. in vivo, and enhanced deconvolution by computational methods. 

Mixture-based synthetic combinatorial libraries. J Med Chem 42 3743-3778... 

Richard A. Houghten, Darcy B. Wilson and Clemencia Pinilla, Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. Drug Discovery Today, 5 (2000), 276—285. 

Houghten, R.A., Pinilla, C., Giulianotti, M.A., Appel, J.R., Dooley, C.T., Nefei, A., Ostresh, J.M., Yu, Y., Maggiora, G.M., Medina-Franco, J.L., Brunner, D., and Schneider, J. (2008) Strategies for the use of mixture-based synthetic combinatorial libraries scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. Journal of Combinatorial Chemistry, 10,3-19. 

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