Mixed intermediate storage

The other operational philosophies that are generally encountered are the mixed intermediate storage (MIS), zero-wait (ZW), finite wait (FW) as well as the unlimited wait (UW) operational philosophies. The MIS philosophy is encountered in a situation where at least 2 of the aforementioned operating philosophies coexist in one process. It is indeed very seldom in most practical applications to have only one philosophy throughout the operation. A combination of different philosophies in often the case. 

These operational policies are not generally taken unilaterally they are generally mixed, which means that the aforementioned operating philosophies coexist in one process, leading to the mixed intermediate storage (MIS) strategy. These situations may correspond to the stable, unstable or stable in limited time namre of the intermediate product as illustrated in... 

Is the new hazard due to potential inadvertent mixing in the staging areas or raw material and intermediates storage areas ... 

It is important to fully understand the physical cleaning cycle and the implications this has on the application of the methodologies. The same cleaning cycle is followed for both the mixing vessels and the intermediate storage vessels. 

There is no single, simple method for determining the optimum mix of storage tanks for a chemical plant. Most often, estimates are made of the minimum and maximum amounts of feeds, intermediates, and products that must be kept on hand. Then some additional allowance is made to permit periodic cleaning and maintenance of the tanks. 

The solids from the pulse-jet baghouse at 440°F are pneumatically conveyed to an intermediate storage silo. About two-thirds of the MgO/ash mixture is returned to the recycle MgO/ash storage silo in the feed preparation area while the remaining one-third enters the ash purge section. In this section the MgO/ash mixture is first reslurried with water and then mixed with 98 sulfuric acid from the acid plant. The... 

If the reaction is to be performed in a continuous setting, two separate sets of equipment are required and must be operated simultaneously. Compositions are then obtained by mixing the necessary streams belonging to each structure in the appropriate proportions. By comparison, if it is desired to perform the same task under batch conditions, an identical outcome may be achieved by two serial operations together with intermediate storage of material used in mixing processes. Hence, it may turn out that a single set of reactive equipment is sufficient to achieve the same result. 

However, in practice, the schedule should satisfy another constraint. After the mixing stage, the ice cream must remain in intermediate storage for several hours before it can be packed to allow the product to age. The minimum required aging time depends on the product. Products A and D have an aging time of 4 h, product B of 8 h, and product C of 12 h. 

Dilution of the prealiquoted compound samples with assay buffer is performed just in time before the screen. A 384-well parallel pipettor on the HTS system adds assay buffer to the compound aliquots in the wells, mixes the diluted compound solutions in the wells, and transfers the amount of compound solution needed for the assay from the sample plate to one or multiple assay plates, which are processed in one screening run on the HTS system. This procedure minimizes degradation of unstable compounds caused by storage of compound collections in aqueous solution over days or even weeks. In addition, it allows very flexible dilution schemes in the assay plates without using intermediate dilution plates. 

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