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Mitomycin pharmacokinetics

Mitomycin C is an alkylating agent that forms cross-links with DNA to inhibit DNA and RNA synthesis. The pharmacokinetics of mitomycin C are best described by a two-compartment model, with an a half-life of 8 minutes and a terminal half-life of 48 minutes.31 Liver metabolism is the primary route of elimination. Mitomycin C has shown clinical activity in the treatment of anal, bladder, cervix, gallbladder, esophageal, and stomach cancer. Side effects consist of myelosuppression and mucositis, and it is a vesicant. [Pg.1292]

Nomura, T., Saikawa, A., Morita, S., Sakaeda (ne Kakutani), T., Yamashita, F., Honda, K., Takakura, Y. and Hashida, M. (1998b) Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection. J. Control Release, 52, 239-252. [Pg.395]

Miya T, Sasaki Y, Karato A, Saijo N. Pharmacokinetic study of mitomycin C with emphasis on the influence of aging. Jpn J Cancer Res 1992 83 1382-5. [Pg.388]

SchilderRB, Young JD, RatanatharathornV, KaranesCand Baker LH. Clinical pharmacokinetics of high-dose mitomycin C. Cancer Chemother Pharmacol, 13 186-190,1984... [Pg.533]

Erlichman C, Rauth AM, Battistella Rand Eine S. Mitomycin C pharmacokinetics in patients with recurrent or metastatic colorectal carcinoma. Can J Physiol Pharmacol, 65 407-411,1987... [Pg.533]

Mechanisms and pharmacokinetics Mitomycin is a CCNS drug that is metabolized by liver enzymes to form an alkylating agent which cross-links DNA. Mitomycin is given intravenously and is rapidly cleared via hepatic metabolism. [Pg.483]

The antibiotics are drugs isolated from the fungal species Streptomyces. They are classified together based solely on their origin. These agents have different mechanisms of action, toxicides, pharmacokinetics and clinical indications. Therefore, it is not useful to simply learn a prototype drug for this class. The most commonly used antibiotics are adriamycin, actinomycin D, mitomycin C and bleomycin. [Pg.128]

Den Harti J, Analysis, electrochemistry and pharmacokinetics of mitomycin C, Thesis, Utrecht, The Nedierlands (1986). [Pg.287]

Fujita T, Tamura T, Yamada H, Yamamoto A, Muranishi S. Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice. J Drug Target 1997 4 289-296. [Pg.234]

A study in 5 patients with advanced solid tumours treated with mitomycin C 10 mg/m showed that furosemide given as a 40 mg intravenous bolus either 120 or 200 minutes after the mitomycin had no effect on its pharmacokinetics. ... [Pg.655]

Guadagni S, Aigner KR, Palumbo G et al (1998) Pharmacokinetics of mitomycin C in pelvic stopilow infusion and hypoxic pelvic perfusion with and without hemofiltration a pilot study of patients with recurrent unresectable rectal cancer. J Clin Pharmacol 38(10) 936-944... [Pg.45]

Andersson M, Aronsen F, Balch C, et al. (1989) Pharmacokinetics of intra-arterial mitomycin-c with or without degradable starch microspheres (DSM) in the treatment of non-resectable liver cancer. Acta Oncol 28 219-222... [Pg.187]

See other pages where Mitomycin pharmacokinetics is mentioned: [Pg.545]    [Pg.16]    [Pg.392]    [Pg.393]    [Pg.533]    [Pg.371]    [Pg.589]    [Pg.37]    [Pg.45]    [Pg.162]   
See also in sourсe #XX -- [ Pg.1292 ]



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