Mitogen-induced mouse splenocyte

B lymphocytes have been reported to express relatively high levels of the CB2 receptor (Carayon et al. 1998 Galiegue et al. 1995 Lynn and Herkenham 1994). Thus, it is not surprising that cannabinoid agonists should exert major effects on their functional activities. Klein et al. (1985) noted that addition of THC to mouse splenocyte cultures suppressed not only T lymphocyte proliferation in response to the mitogens ConA and PHA, but also that of B lymphocytes induced by LPS, a B cell mitogen. The hydroxylated metabolite of THC, 11 -hydroxy-THC, was observed to be much less potent in this inhibition. 

Hayek, M.G., Meydani, S.N., Meydani, M., and Blumberg, J.B. (1994) Age Differences in Eicosanoid Production of Mouse Splenocytes Effects on Mitogen-Induced T-Cell Proliferation, J. Gerontol. 49, B197-B207. 

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