Mitochondrial glycerol-3-phosphate

Figure 18.5 The glycerol-3-phosphate shuttle. This shuttle is used to bring electrons from cytosolic NADH into mitochondria. The mitochondrial glycerol-3-phosphate dehydrogenase with its FAD prosthetic group is bound to the inner mitochondrial membrane. ETF is electron transfer flavoprotein, which extracts electrons from the FADH2 of mitochondrial glycerol-3-phosphate dehydrogenase and with it reduces ubiquinone (UQ).

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Ascofuranone (9), an isoprenoid prenylphenol antibiotic, derived from the fungus Ascochyta visiae, specifically inhibits mitochondrial glycerol-3-phosphate (G-3-P)-dependent electron transport in T. b. brucei [44]. Ascofuranone strongly inhibited both glucose-dependent cellular respiration and glycerol-3-phosphate-dependent mitochondrial oxygen consumption of T. b. brucei bloodstream form... 

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