Mitochondrial electron transport fungicides

Carboxamides are a group of fungicides that control diseases caused by Basidiomycete type fungi (42). The best known member of this group is carboxin (Figure 6). Carboxamides specifically block membrane bound succinate-ubiquinone oxldoreductase activity in the mitochondrial electron transport chain (42, ). The carboxin receptor in the succinic dehydrogenase complex (SDC) is believed to be the iron-sulfur cluster Sj complexed with small coenzyme Q binding polypeptide(s) in a phospholipid environment (45.46 >. 

Fluacrypyrim (73 2002, Titaron , Nippon Soda) [118] is the first strobilurin analogue to be marketed as an acaricide rather than a fungicide - it inhibits mitochondrial electron transport at complex III of the respiratory chain. It is active against all growth stages of spider mites and shows an acaricidal contact and... 

Inhibition of electron transport in the mitochondrial respiratory chain No cross-resistance to other fungicide classes A good tool for resistance management of other fungicides Resistance management will be required on risky pathogens... 

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